abstract：:We studied proliferation, migration, and secretion of NO by bone marrow multipotent mesenchymal stromal cells from Wistar rats during conditioning under hypoxic and hyperglycemic conditions and the effect of erythropoietin on these parameters. A stimulating effect of erythropoietin on cell proliferation under normal c...

journal_title：Bulletin of experimental biology and medicine

authors： Lykov AP,Nikonorova YV,Bondarenko NA,Poveshchenko OV,Kim II,Poveshchenko AF,Konenkov VI

更新日期：2015-08-01 00:00:00

abstract：:Immunohistochemistry with semi-quantitative analysis of computer images showed that prolactin receptor and cystic fi brosis transmembrane regulator (CFTR) in cholangiocytes of female rats elevated in cholestasis quickly respond to its relief. The effect of hyperprolactinemia on the extent of return of these proteins t...

journal_title：Bulletin of experimental biology and medicine

authors： Aleksandrova MI,Sirotina NS,Smirnova OV

更新日期：2015-07-01 00:00:00

abstract：:We proposed a new indicator for evaluation of functional activity of Ca(2+) in human blood serum based on lysis of sheep erythrocytes with 10% human blood serum in the presence of 0.55 mM ethylene glycol tetraacetic acid at 37°C for 10 min. After incubation, the degree of sheep erythrocytes lysis inhibition is estimat...

journal_title：Bulletin of experimental biology and medicine

authors： Shoibonov BB,Grigor'eva DV,Shabalina AA,Kostyreva MV,Baronets VY,Zamolodchikova TS

更新日期：2015-07-01 00:00:00

abstract：:In rat sinoatrial node, NAD(+) (10 μM) reduced the rate of spontaneous action potentials, duration of action potentials, and the velocity of slow diastolic depolarization, but the rate of action potential front propagation increases. In passed rabbit Purkinje fibers, NAD(+) (10 μM) reduced the duration of action poten...

journal_title：Bulletin of experimental biology and medicine

authors： Pustovit KB,Kuz'min VS,Sukhova GS

更新日期：2015-06-01 00:00:00

abstract：:Cell cultures isolated by the enzymatic method from the terminal placenta amnion consist mainly from epithelial cells, expressing cytokeratin-7, CD90, and CD73, are characterized by high viability and low proliferative potential. Adhesive cultures of umbilical (Wharton's jelly) cells, despite the fibroblast-like shape...

journal_title：Bulletin of experimental biology and medicine

authors： Rylova YV,Milovanova NV,Gordeeva MN,Savilova AM

更新日期：2015-06-01 00:00:00

abstract：:Experiments on rat model of toxic liver damage (CCl4, subcutaneously) have demonstrated that selenium nanopreparation on arabinogalactan matrix and partially arabinogalactan alone prevented the development of oxidative stress assessed by the balance of LPO and antioxidant defense processes. ...

journal_title：Bulletin of experimental biology and medicine

authors： Kolesnikova LI,Karpova EA,Vlasov BY,Sukhov BG,Mov BA

更新日期：2015-06-01 00:00:00

abstract：:The paper presents the basic criteria for glycemic control in type 2 diabetes mellitus, the data on the relationship between postprandial glycemia and the development of the late vascular complications, and methods for evaluating the glycemic index of foodstuffs and dishes in order to optimize the diets and improve th...

journal_title：Bulletin of experimental biology and medicine

authors： Sharafetdinov KhKh,Lapik IA,Vorozhko IV,Tutelyan VA

更新日期：2015-05-01 00:00:00

abstract：:Results of long-term prospective follow-up of patients with early stages of mitral and aortic valvulitis and primary chronic septic endocarditic are presented. Clinical diagnostics of the diseases is described and the key role is assigned to pathognomic (absolute) clinical symptoms. The tendency to progressive fibrosi...

journal_title：Bulletin of experimental biology and medicine

authors： Bushmanova GM,Zorina IG,Nikityuk DB,Nepomnyashchikh RD,Lapii GA,Postnikova OA,Semenov DE

更新日期：2015-05-01 00:00:00

abstract：:Muramyl dipeptide β-heptylglycoside (C7MDP) was administered to non-pregnant CBA female mice and pregnant mice after non-abortion-prone mating (CBA×BALB/c) and mating associated with a high rate of spontaneous abortion (CBA×DBA/2). In non-pregnant females, C7MDP increased the production of IL-2, IL-4, IL-5, IL-6, IL-1...

journal_title：Bulletin of experimental biology and medicine

authors： Kalyuzhin OV,Artem'eva KA,Boltovskaya MN,Bunyatyan KA,Inviyayeva EV,Vinnitskii LI,Karaulov AV

更新日期：2015-05-01 00:00:00

abstract：:A composition containing culture medium conditioned by mesenchymal stem cells and mesenchymal stem cell lysate improves biochemical parameters, reduces inflammation, and stimulates regenerative processes in the liver. ...

journal_title：Bulletin of experimental biology and medicine

authors： Khubutiya MSh,Temnov AA,Vagabov VA,Sklifas AN,Rogov KA,Zhgutov YA

更新日期：2015-05-01 00:00:00

abstract：:We performed morphofunctional analysis of cultured rabbit buccal epithelial cells in the primary culture, during passaging, and upon interaction with collagen substrates. Three different morphological types were identified. It was demonstrated that precursors of rabbit buccal epithelium were characterized by high prol...

journal_title：Bulletin of experimental biology and medicine

authors： Chentsova EV,Konyushko OI,Makarov MS,Egorova NS,Zinov'ev MY,Borovkova NV

更新日期：2015-05-01 00:00:00

abstract：:The distribution of polymorphic variants of innate immunity genes TLR9 (+2848G>A) and DEFB1(-20G>A; -44C>G; -52G>A) was evaluated in long-living individuals. No significant differences were found in the distribution of genotypes and alleles of the TLR9 gene. The following features were revealed: increase in the freque...

journal_title：Bulletin of experimental biology and medicine

authors： Gankovskaya LV,Svitich OA,Artem'eva OV,Miroshnichenkova AM,Rusanova KV

更新日期：2015-05-01 00:00:00

abstract：:MEK, PI3, p38, tyrosine, and mTOR kinases are not involved in the regulation of heart resistance to the arrhythmogenic action of short-term ischemia/reperfusion in non-adapted rats. ...

journal_title：Bulletin of experimental biology and medicine

authors： Maslov LN,Mukhomedzyanov AV,Tsibulnikov SY,Chauski EI,Khaliulin IG,Portnichenko AG

更新日期：2015-04-01 00:00:00

abstract：:The mechanisms of therapeutic resistance of human glioblastoma multiforme are analyzed. The authors make an attempt at systematization and scientific theoretical validation of new approaches to creation of biomedical cellular preparations, based on the oncoproteomic technologies, for personified therapy of the glial t...

journal_title：Bulletin of experimental biology and medicine

authors： Bryukhovetskii IS,Bryukhovetskii AS,Khotimchenko YS

更新日期：2015-04-01 00:00:00

abstract：:The cardioprotective effects of Ganoderma lucidum extract were examined in experiments with global ischemia (45 min) and reperfusion (30 min) of isolated and perfused rat heart. The course of preventive administration of the extract in a dose of 400 mg/kg for 15 days diminished necrotic death of cardiomyocytes and red...

journal_title：Bulletin of experimental biology and medicine

authors： Lasukova TV,Maslov LN,Arbuzov AG,Burkova VN,Inisheva LI

更新日期：2015-04-01 00:00:00

abstract：:We analyzed ultrastruciture of the cell populations in the prostate gland in chronic nonbacterial prostatitis in a chemical industry worker. It was shown that ultrastructural reorganization of the epithelium consisted in reduction of the secretory compartment of the cytoplasm and dystrophic-degenerative changes in cel...

journal_title：Bulletin of experimental biology and medicine

authors： Nepomnyashchikh LM,Lapiy GA,Nikityuk DB,Neimark AI,Kiptilov AV,Molodykh OP

更新日期：2015-04-01 00:00:00

abstract：:Age-related development of behavioral disorders in transgenic mice with modeled Alzheimer's disease carrying V6S3-Tg(APP695)85Dbo Tg(PSENI)85Dbo) genotype was assessed at the age of 7.5, 10 and 20 months in the following tests: open-field, plus maze, T-maze, conditioned passive avoidance response, rotarod, conflict si...

journal_title：Bulletin of experimental biology and medicine

authors： Semina II,Baichurina AZ,Makarova EA,Leushina AV,Kazakevich ZhV,Gabdrakhmanova MR,Mukhamed'yarov MA,Zefirov AL

更新日期：2015-03-01 00:00:00

abstract：:We studied the effect of anti-inflammatory cytokine IL-4 (5 μg/kg intraperitoneally) on peripheral blood leukocytes in Wistar rats with various behavioral characteristics during acute emotional stress (1-h immobilization with simultaneous subthreshold electrocutaneous stimulation). IL-4 reduced the differences in bloo...

journal_title：Bulletin of experimental biology and medicine

authors： Pertsov SS,Koplik EV,Kalinichenko LS

更新日期：2015-03-01 00:00:00

abstract：:According modern biological hypotheses of the pathogenesis of affective disorders, hypothalamic-pituitary-adrenal axis dysfunction play a special role in the pathogenesis of this condition. Our study shows that the range of neuroprotective neurosteroids is gender- and nosology-dependent. Patients with affective disord...

journal_title：Bulletin of experimental biology and medicine

authors： Levchuk LA,Vyalova NM,Ivanova SA,Simutkin GG,Lebedeva EV,Bokhan NA

更新日期：2015-03-01 00:00:00

abstract：:Local inflammatory response in the lungs and fi brogenic potential of multi-walled carbon nanotubes were studied in an acute aspiration experiment in mice. The doses were chosen based on the concentration of nanotubes in the air at a workplace of the company-producer. ELISA, fl ow cytometry, enhanced darkfield microsc...

journal_title：Bulletin of experimental biology and medicine

authors： Khaliullin TO,Shvedova AA,Kisin ER,Zalyalov RR,Fatkhutdinova LM

更新日期：2015-03-01 00:00:00

abstract：:We performed a comparative analysis of biological activity of Lys-Glu peptide and its amino acid constituents. It was established that Lys-Glu stimulated proliferation of splenic cells in organotypic culture, while the mixture of glutamic acid and lysine inhibited culture growth. Using the method of molecular docking,...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VKh,Tarnovskaya SI,Lin'kova NS,Chervyakova NA,Nichik TE,Elashkina EV,Chalisova NI

更新日期：2015-02-01 00:00:00

abstract：:Local application of ointment with Bacillus spp. strain MG8 (15,000-20,000 living bacterial cells), isolated from permafrost specimens, on the skin wound of about 60 mm(2) stimulated the reparation processes in experimental mice. A possible mechanism stimulating the regeneration of the damaged tissues under the effect...

journal_title：Bulletin of experimental biology and medicine

authors： Kalenova LF,Novikova MA,Subbotin AM

更新日期：2015-02-01 00:00:00

abstract：:We studied the effect of VEGF-A in experimental myocardial infarction on attraction of progenitor cells into the regeneration zone. The appearance of CD34(+)CD45(+) cells known as low-differentiated progenitor cells was observed in the damaged myocardial tissue in the presence of a considerable excess of VEGF-A. These...

journal_title：Bulletin of experimental biology and medicine

authors： Shurygin MG,Shurygina IA,Dremina NN,Kanya OV

更新日期：2015-02-01 00:00:00

abstract：:The involvement of PI3K, ERK and p38-dependent signaling system in the regulation of functional activity of erythroid precursors after blood loss (30% of circulating volume) was studied. We demonstrated the important role of PI3K and p38 in the suppression of differentiation of erythroid precursors the contribution of...

journal_title：Bulletin of experimental biology and medicine

authors： Dygai AM,Zhdanov VV,Miroshnichenko LA,Udut EV,Zyuz'kov GN,Simanina EV,Sherstoboev EY,Chaikovskii AV,Stavrova LA,Burmina YV,Khrichkova TY,Reichart DV,Goldberg VE

更新日期：2015-02-01 00:00:00

abstract：:A simple method for the diagnosis of insulin resistance, easily realized in clinical practice, is developed in order to detect patients at a high risk of diseases associated with this condition. The metabolic index is estimated as the proportion of triglycerides and glucose values to quadratic HDL cholesterol value (i...

journal_title：Bulletin of experimental biology and medicine

authors： Roitberg GE,Dorosh ZhV,Sharkhun OO

更新日期：2015-01-01 00:00:00

abstract：:Experiments on the model of mouse BCG-induced granulomatous showed that the content of glycosaminoglycans and proteoglycans in the extracellular matrix of the liver and lungs are changed at the early stages of inflammation (days 3 and 30 postinfection) before cell destruction in the organs begins. This is related to d...

journal_title：Bulletin of experimental biology and medicine

authors： Kim LB,Shkurupy VA,Putyatina AN

更新日期：2015-01-01 00:00:00

abstract：:The linear parameters and number of Langerhans islets were evaluated in rats with alloxaninduced diabetes mellitus after transplantation of fetal pancreatic tissue to the anterior chamber of the eye. The islets significantly increased in size by week 3 after surgery and a trend to an increase in their number was obser...

journal_title：Bulletin of experimental biology and medicine

authors： Kulikov DA,Kulikov AV,Arkhipova LV,Smirnova GN,Dreval' AV,Tikhonova LP,Gaivoronskii IV,Sukhikh GT

更新日期：2015-01-01 00:00:00

abstract：:The effects of two derivatives of 2-aminoadamantane, enantiomers J447H and J579, on the behavior of male and female C57Bl/6J mice were studied using a modified light/dark test. The substances differed by their effects on the behavior of male mice. J579 reduced the number of rearings. J447H in a dose of 1 mg/kg affecte...

journal_title：Bulletin of experimental biology and medicine

authors： Avgustinovich DF,Fomina MK,Suslov EV,Tolstikova TG,Volcho KP,Salakhutdinov NF

更新日期：2014-12-01 00:00:00

abstract：:High doses of phenylephrine and diazepam (1 and 10 mg/kg, respectively) suppressed the development of generalized tonic-clonic pentylenetetrazole-induced convulsions in 86-100% rats, but did not prevent local clonic pentylenetetrazole-induced convulsions. Diazepam in the specified dose produced strong sedation, while ...

journal_title：Bulletin of experimental biology and medicine

authors： Serdyuk SE,Gmiro VE

更新日期：2014-12-01 00:00:00

abstract：:Total antioxidant activity of the serum in patients with liver pathology was assessed by two chemiluminescent methods based on different models of free radical oxidation: Hb-H2O2-luminol and ABAP-luminol. Comparative analysis showed a significant, but not high correlation of the results (r=0.798), which can be explain...

journal_title：Bulletin of experimental biology and medicine

authors： Titov VN,Sazhina NN

更新日期：2014-12-01 00:00:00

abstract：:Kinetics of DNA synthesis in mitotic cycle of in mouse corneal epithelial cells after γ-irradiation in different S phase points was studied by the method of autoradiography. Normally, S phase of corneal epithelial cells consists of two phases (S1 and S2) separated by an interval without DNA synthesis. Each phase, in t...

journal_title：Bulletin of experimental biology and medicine

authors： Shabalkin IP,Grigor'eva EY,Shabalkin PI,Gudkova MV

更新日期：2014-11-01 00:00:00

abstract：:We studied the effect of experimental liver injury of various origins (toxic, autoimmune, alcoholic, and mesenchymal) in the females on motility of spermatozoa in the offspring. The number of infertile (jerking and immotile) spermatozoa increased, whereas the number of fertile spermatozoa (progressive motile and slow ...

journal_title：Bulletin of experimental biology and medicine

authors： Bryukhin GV,Sizonenko ML

更新日期：2014-11-01 00:00:00

abstract：:Drug resistance and viability of Mycobacterium tuberculosis were studied in 637 patients with pulmonary tuberculosis, detected by screening fluorography (group 1) and in 909 patients in whom the specific process was detected when they applied for medical care (group 2). The mycobacteria in the two groups did not diffe...

journal_title：Bulletin of experimental biology and medicine

authors： Koretskaya NM,Narkevich AN

更新日期：2014-11-01 00:00:00

abstract：:Oxidized dextran is suggested for prevention of infection induced by influenza A/H5N1 viruses, methods of its use and doses are determined. Two intravenous injections of dextran 3 and 1 days before experimental infection of outbred mice by influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus resulted in a high preven...

journal_title：Bulletin of experimental biology and medicine

authors： Shkurupy VA,Potapova OV,Sharkova TV,Troitskii AV,Gulyaeva EP,Bystrova TN,Shestopalov AM

更新日期：2014-11-01 00:00:00

abstract：:Anticonvulsant activity and pharmacokinetics of nanoemulsion and unmodified substance of carbamazepine were compared in experiments on mice. Carbamazepine nanoemulsion demonstrated significant anticonvulsant activity and was superior to unmodified substance of carbamazepine against seizures induced by maximum electric...

journal_title：Bulletin of experimental biology and medicine

authors： Prokhorov DI,Sariev AK,Abramov DA,Voronina TA,Kapitsa IG,Zhuravko AS,Shiriaeva MV,Kaplun AP,Seifulla RD

更新日期：2014-10-01 00:00:00

abstract：:Precise location of IL-18 in cell and tissue elements of the atherosclerotic lesions in humans and its role in destabilization of the atherosclerotic plaque were detected. The data suggested a hypothesis on indirect involvement of IL-18 in destruction of the elastic and collagen fibers in an unstable plaque due to thi...

journal_title：Bulletin of experimental biology and medicine

authors： Pigarevskii PV,Maltseva SV,Snegova VA,Davydova NG

更新日期：2014-10-01 00:00:00

abstract：:We studied the course and outcome of pregnancy in the model of inflammation of internal genital organs in female rats. It was shown that inflammation of internal genital organs impairing the state of the lymphatic region of the uterus and adnexa and relationship between the drainage and detoxification function therein...

journal_title：Bulletin of experimental biology and medicine

authors： Dergacheva TI,Borodin YI,Konenkov VI

更新日期：2014-10-01 00:00:00

abstract：:Proinflammatory markers were evaluated in patients with chronic heart failure of ischemic origin and essential hypertension with preserved left-ventricular ejection fraction before and after a 6-month course of simvastatin therapy (20 mg/day). The study was carried out in 125 patients with diastolic dysfunction manife...

journal_title：Bulletin of experimental biology and medicine

authors： Pinchuk TV,Fedulaev YN,Khairetdinova GA,Denisova NN,Chura OV,Logunova IY

更新日期：2014-09-01 00:00:00

abstract：:Isolated perfused rat heart was subjected to global ischemia (45 min) followed by reperfusion (30 min). Under these conditions, the level of creatine phosphokinase in the perfusate increased by 4.5 times. Perfusion (10 min) of the isolated heart with a solution containing cannabinoid HU-210 (0.1 or 1.0 μmol/liter) was...

journal_title：Bulletin of experimental biology and medicine

authors： Maslov LN,Krylatov AV,Lishmanov YB

更新日期：2014-09-01 00:00:00

abstract：:The development of dissociated cells from rat embryonic spinal ganglion after transplantation to damaged nerve of adult animals was studied using immunohistochemical differentiation markers of neural and glial cells. The cell suspension obtained after dissociation of rat embryonic spinal ganglia (embryonic day 15) was...

journal_title：Bulletin of experimental biology and medicine

authors： Petrova ES,Isaeva EN,Korzhevskii DE

更新日期：2014-09-01 00:00:00